Regularly topping the lists of the best beaches, Sanibel Island has a world of adventure tucked into one easily navigable island – with zero stoplights. Find a beach resort or choose your own private cottage or quaint inn. From your home base, you can explore 15 miles of unspoiled beaches, where collecting unique seashells is a beloved pastime. On Sanibel Island, 25 miles of multi-use paths function as sidewalks, bicycle paths and recreational trails beside buildings no taller than the tallest palm tree.

On an island where more than half of the land has been preserved against development, an essential highlight is the 6,400-acre J.N. "Ding" Darling National Wildlife Refuge. Explore the refuge's popular Wildlife Drive by vehicle or bicycle, or hop aboard a tram for a guide tour to spot hundreds of species of shorebirds, waterfowl and wading birds.

Art galleries also hold an inspiring presence on Sanibel Island, with monthly Art Nights during the winter. Seashell shops, resort clothing boutiques and jewelry stores selling custom, sea-inspired adornments line small shopping centers festooned with bougainvillea, shady ficus trees and swaying palms. Take your pick from many amazing restaurants, with menus ranging from seafood to home-cooked Italian.